Assay Detail
Binding
CHEMBL648566
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Tested for inhibition of Angiotensin II receptor, type 1 in the absence of bovine serum albumin (BSA)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Valsartan, a potent, orally active angiotensin II antagonist developed from the structurally new amino acid series
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.32 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1069 | VALSARTAN | 4.0 | 1 | 8.57 |
| CHEMBL116298 | — | — | 1 | 8.22 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.10 |
| CHEMBL112523 | — | — | 1 | 7.62 |
| CHEMBL115783 | — | — | 1 | 7.52 |
| CHEMBL326349 | — | — | 1 | 7.22 |
| CHEMBL117941 | — | — | 1 | 7.22 |
| CHEMBL114653 | — | — | 1 | 6.70 |
| CHEMBL323911 | — | — | 1 | 6.57 |
| CHEMBL115622 | — | — | 1 | 6.52 |
| CHEMBL326140 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1069 | VALSARTAN | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL116298 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL191 | LOSARTAN | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL112523 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL115783 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL326349 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL117941 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL114653 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL323911 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL115622 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL326140 | — | IC50 | = | 600.0 | nM | 6.22 |