Assay Detail
Binding
CHEMBL648579
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potent and orally active angiotensin II receptor antagonists with equal affinity for human AT1 and AT2 subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.96 | 9.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338434 | — | — | 1 | 9.06 |
| CHEMBL339722 | — | — | 1 | 8.92 |
| CHEMBL339256 | — | — | 1 | 8.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338434 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL339722 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL339256 | — | IC50 | = | 1.3 | nM | 8.89 |