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Assay Detail

CHEMBL648786

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Ability to displace beta ([125I]-iodo-4-hydroxyphenyl)-ethylaminomethyl tetralone from human cloned Alpha-1a adrenergic receptor stably expressed in HEK cells
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type HEK293
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Alpha-1A adrenergic receptor (CHEMBL229)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design and synthesis of N-alkylated saccharins as selective alpha-1a adrenergic receptor antagonists.
Nerenberg JB, Erb JM, Thompson WJ, Lee HY, Guare JP, Munson PM, Bergman JM, Huff JR, Broten TP, Chang RS, Chen TB, O'Malley S, Schorn TW, Scott AL.
Bioorg Med Chem Lett (1998) 8 : 2467 -2472
PubMed 9873563 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 9.57 9.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL83592 1 9.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL83592 Ki = 0.27 nM 9.57