Assay Detail
Binding
CHEMBL648787
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Binding affinity against human Alpha-1a adrenergic receptor
22
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of novel dihydropyridine alpha-1a antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 8.27 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5483012 | — | — | 1 | 9.46 |
| CHEMBL323579 | — | — | 4 | 9.40 |
| CHEMBL95548 | — | — | 1 | 8.86 |
| CHEMBL432026 | — | — | 1 | 8.77 |
| CHEMBL180561 | — | — | 1 | 8.73 |
| CHEMBL95253 | — | — | 1 | 8.52 |
| CHEMBL322405 | — | — | 1 | 8.50 |
| CHEMBL95736 | — | — | 1 | 8.42 |
| CHEMBL316495 | — | — | 1 | 8.42 |
| CHEMBL95434 | — | — | 1 | 8.36 |
| CHEMBL95290 | — | — | 1 | 8.35 |
| CHEMBL95578 | — | — | 1 | 8.32 |
| CHEMBL99864 | — | — | 1 | 8.29 |
| CHEMBL330401 | — | — | 1 | 8.20 |
| CHEMBL320736 | — | — | 1 | 7.94 |
| CHEMBL100045 | — | — | 1 | 7.71 |
| CHEMBL95263 | — | — | 1 | 6.90 |
| CHEMBL98038 | — | — | 1 | 6.34 |
| CHEMBL1491 | AMLODIPINE | 4.0 | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5483012 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL323579 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL323579 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL323579 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL95548 | — | Ki | = | 1.37 | nM | 8.86 |
| CHEMBL432026 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL180561 | — | Ki | = | 1.87 | nM | 8.73 |
| CHEMBL95253 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL322405 | — | Ki | = | 3.15 | nM | 8.50 |
| CHEMBL316495 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL95736 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL95434 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL95290 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL95578 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL99864 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL323579 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL330401 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL320736 | — | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL100045 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL95263 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL98038 | — | Ki | = | 455.0 | nM | 6.34 |
| CHEMBL1491 | AMLODIPINE | Ki | = | 2344.0 | nM | 5.63 |