Assay Detail
Binding
CHEMBL648792
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its binding affinity towards CHO cells expressing human Alpha-1a adrenergic receptor by displacing [125I]HEAT (2-beta-(4-hydroxyphenyl)-ethylaminomethyltetralone)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Marine sponge bis(indole) alkaloids that displace ligand binding to 1 adrenergic receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.96 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302882 | — | — | 1 | 6.85 |
| CHEMBL63208 | NORTOPSENTIN C | — | 1 | 6.26 |
| CHEMBL292801 | NORTOPSENTIN B | — | 1 | 6.11 |
| CHEMBL302637 | NORTOPSENTIN A | — | 1 | 5.67 |
| CHEMBL436760 | BROMOTOPSENTIN | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302882 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL63208 | NORTOPSENTIN C | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL292801 | NORTOPSENTIN B | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL302637 | NORTOPSENTIN A | Ki | = | 2140.0 | nM | 5.67 |
| CHEMBL436760 | BROMOTOPSENTIN | Ki | = | 12590.0 | nM | 4.90 |