Assay Detail
Binding
CHEMBL648957
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Inhibition of [125I]angiotensin II specific binding to rat mesenteric arteries
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Imidazole-5-acrylic acids: potent nonpeptide angiotensin II receptor antagonists designed using a novel peptide pharmacophore model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.44 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL125786 | — | — | 1 | 7.24 |
| CHEMBL126594 | — | — | 1 | 6.92 |
| CHEMBL339961 | — | — | 1 | 6.82 |
| CHEMBL126356 | — | — | 1 | 6.60 |
| CHEMBL339446 | — | — | 1 | 6.52 |
| CHEMBL127005 | — | — | 1 | 6.44 |
| CHEMBL338478 | — | — | 1 | 6.33 |
| CHEMBL126359 | — | — | 1 | 6.09 |
| CHEMBL339860 | — | — | 1 | 6.09 |
| CHEMBL338517 | — | — | 1 | 6.09 |
| CHEMBL127379 | — | — | 1 | 6.07 |
| CHEMBL436594 | — | — | 1 | 5.92 |
| CHEMBL444069 | — | — | 1 | 5.72 |
| CHEMBL127308 | — | — | 1 | 5.54 |
| CHEMBL126501 | — | — | 1 | 5.44 |
| CHEMBL339623 | — | — | 1 | 5.34 |
| CHEMBL338067 | — | — | 1 | 5.28 |
| CHEMBL338249 | — | — | 1 | 5.17 |
| CHEMBL405525 | — | — | 1 | 5.16 |
| CHEMBL126500 | — | — | 1 | 5.05 |
| CHEMBL338690 | — | — | 1 | 5.01 |
| CHEMBL127916 | — | — | 1 | 4.92 |
| CHEMBL339939 | — | — | 1 | 4.84 |
| CHEMBL127515 | — | — | 1 | 4.78 |
| CHEMBL127566 | — | — | 1 | 4.77 |
| CHEMBL125341 | — | — | 1 | 4.73 |
| CHEMBL127137 | — | — | 1 | 4.72 |
| CHEMBL434254 | — | — | 1 | 4.70 |
| CHEMBL435804 | — | — | 1 | 4.66 |
| CHEMBL340433 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL125786 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL126594 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL339961 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL126356 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL339446 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL127005 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL338478 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL126359 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL339860 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL338517 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL127379 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL436594 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL444069 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL127308 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL126501 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL339623 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL338067 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL338249 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL405525 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL126500 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL338690 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL127916 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL339939 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL127515 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL127566 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL125341 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL127137 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL434254 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL435804 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL340433 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL338423 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL126357 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL340316 | — | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL339121 | — | IC50 | = | 33900.0 | nM | 4.47 |
| CHEMBL353234 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL420515 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL340917 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL291114 | — | IC50 | = | 124000.0 | nM | - |
| CHEMBL2111841 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL341011 | — | IC50 | = | 127000.0 | nM | - |