Assay Detail
Binding
CHEMBL648975
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Ability to inhibit the rat muscle adenylate kinase lII in competition with the AMP varied
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
GTP:AMP phosphotransferase AK3, mitochondrial (CHEMBL4799) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Species- or isozyme-specific enzyme inhibitors. 4. Design of a two-site inhibitor of adenylate kinase with isozyme selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.93 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL604399 | — | — | 2 | 7.16 |
| CHEMBL437508 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL604399 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL604399 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL437508 | — | Ki | = | 300.0 | nM | 6.52 |