Assay Detail
Binding
CHEMBL648979
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Competitive binding inhibition constant of rat Adenylate kinase III was determined
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
GTP:AMP phosphotransferase AK3, mitochondrial (CHEMBL4799) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Species- or isozyme-specific enzyme inhibitors. 4. Design of a two-site inhibitor of adenylate kinase with isozyme selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.16 | 4.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3251359 | — | — | 1 | 4.16 |
| CHEMBL3251363 | — | — | 1 | - |
| CHEMBL1744388 | — | — | 1 | - |
| CHEMBL1744387 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3251359 | — | Ki | = | 70000.0 | nM | 4.16 |
| CHEMBL3251363 | — | Ki | = | 320000.0 | nM | - |
| CHEMBL1744388 | — | Ki | = | 3000000.0 | nM | - |
| CHEMBL1744387 | — | Ki | = | 4800000.0 | nM | - |