Assay Detail
Binding
CHEMBL649147
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Inhibition of eel acetylcholinesterase (AChE) activity by 50%
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.80 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146158 | — | — | 1 | 5.52 |
| CHEMBL32768 | — | — | 1 | 5.16 |
| CHEMBL33332 | — | — | 1 | 5.16 |
| CHEMBL538352 | — | — | 1 | 4.92 |
| CHEMBL33101 | — | — | 1 | 4.92 |
| CHEMBL34000 | — | — | 1 | 4.82 |
| CHEMBL32585 | — | — | 1 | 4.80 |
| CHEMBL416772 | — | — | 1 | 4.70 |
| CHEMBL149427 | — | — | 1 | 4.35 |
| CHEMBL284692 | — | — | 1 | 4.30 |
| CHEMBL288316 | — | — | 1 | 4.10 |
| CHEMBL289890 | — | — | 1 | - |
| CHEMBL358323 | — | — | 1 | - |
| CHEMBL748 | PRALIDOXIME CHLORIDE | 4.0 | 1 | - |
| CHEMBL539108 | — | — | 1 | - |
| CHEMBL33051 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146158 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL32768 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL33332 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL538352 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL33101 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL34000 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL32585 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL416772 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL149427 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL284692 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL288316 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL289890 | — | IC50 | = | 290000.0 | nM | - |
| CHEMBL358323 | — | IC50 | = | 180000.0 | nM | - |
| CHEMBL748 | PRALIDOXIME CHLORIDE | IC50 | = | 185000.0 | nM | - |
| CHEMBL539108 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL33051 | — | IC50 | = | 800000.0 | nM | - |