Assay Detail
Binding
CHEMBL649148
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Compound was tested for the competitive inhibition of phosphorylation of Eel acetylcholinesterase (AChE)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.08 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33332 | — | — | 1 | 5.46 |
| CHEMBL34000 | — | — | 1 | 5.40 |
| CHEMBL32585 | — | — | 1 | 5.12 |
| CHEMBL289890 | — | — | 1 | 4.32 |
| CHEMBL748 | PRALIDOXIME CHLORIDE | 4.0 | 1 | - |
| CHEMBL33051 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33332 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL34000 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL32585 | — | Ki | = | 7600.0 | nM | 5.12 |
| CHEMBL289890 | — | Ki | = | 48000.0 | nM | 4.32 |
| CHEMBL748 | PRALIDOXIME CHLORIDE | Ki | = | 126500.0 | nM | - |
| CHEMBL33051 | — | Ki | = | 228800.0 | nM | - |