Assay Detail
Binding
CHEMBL649418
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Concentration that causes 50% inhibition of mammalian alpha-glucosidase (lysosomal) was determined in rat liver
6
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.76 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 3 | 6.40 |
| CHEMBL312653 | — | — | 1 | 4.04 |
| CHEMBL2114189 | — | — | 1 | 4.00 |
| CHEMBL2115197 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307429 | DUVOGLUSTAT | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL307429 | DUVOGLUSTAT | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL312653 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL2114189 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL307429 | DUVOGLUSTAT | IC50 | = | 1000000.0 | nM | - |
| CHEMBL2115197 | — | IC50 | = | 610000.0 | nM | - |