Assay Detail
Binding
CHEMBL649440
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Alpha-1 adrenergic receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationship of N-(phenylalkyl)cinnamides as novel NR2B subtype-selective NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.00 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113830 | (S,R)-IFENPRODIL | — | 1 | 7.00 |
| CHEMBL113990 | — | — | 1 | - |
| CHEMBL440298 | — | — | 1 | - |
| CHEMBL115388 | — | — | 1 | - |
| CHEMBL113919 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113830 | (S,R)-IFENPRODIL | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL113990 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL440298 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL115388 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL113919 | — | IC50 | > | 100000.0 | nM | - |