Assay Detail
Binding
CHEMBL649492
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Compound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel human metabolites of the angiotensin-II antagonist tasosartan and their pharmacological effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.45 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72053 | — | — | 1 | 7.64 |
| CHEMBL432162 | TASOSARTAN | 2.0 | 1 | 7.42 |
| CHEMBL291944 | — | — | 1 | 7.36 |
| CHEMBL307191 | — | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72053 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL432162 | TASOSARTAN | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL291944 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL307191 | — | IC50 | = | 44.0 | nM | 7.36 |