Assay Detail
Functional
CHEMBL649516
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested in vitro for inhibition of amylase release from rat pancreatic acini
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of cholecystokinin analogs in which the Asp-Phe-NH2 moiety has been replaced by a 3-amino-7-phenylheptanoic acid or a 3-amino-6-(phenyloxy)hexanoic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.98 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386811 | — | — | 1 | 9.52 |
| CHEMBL263876 | — | — | 1 | 9.30 |
| CHEMBL414180 | — | — | 1 | 9.00 |
| CHEMBL385918 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386811 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL263876 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL414180 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL385918 | — | IC50 | = | 8.0 | nM | 8.10 |