Assay Detail
Binding
CHEMBL649552
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Compound was tested for its specificity against AmpC beta-lactamase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.62 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34964 | — | — | 1 | 6.82 |
| CHEMBL143399 | — | — | 1 | 6.22 |
| CHEMBL142592 | — | — | 1 | 5.70 |
| CHEMBL140740 | M(DANSYLAMIDOPHENYL)BORONIC ACID | — | 1 | 5.30 |
| CHEMBL140723 | — | — | 1 | 5.30 |
| CHEMBL20945 | — | — | 1 | 5.30 |
| CHEMBL336239 | — | — | 1 | 5.30 |
| CHEMBL141272 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34964 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL143399 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL142592 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL140740 | M(DANSYLAMIDOPHENYL)BORONIC ACID | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL140723 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL20945 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL336239 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL141272 | — | IC50 | = | 10000.0 | nM | 5.00 |