Assay Detail
Binding
CHEMBL649566
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Competitive Inhibitory activity against Endoplasmic reticulum Alpha-Glucosidase II
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.12 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 1 | 5.89 |
| CHEMBL1029 | MIGLUSTAT | 4.0 | 1 | 5.43 |
| CHEMBL75971 | — | — | 1 | 5.24 |
| CHEMBL80254 | — | — | 1 | 5.01 |
| CHEMBL310229 | — | — | 1 | 4.02 |
| CHEMBL80148 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307429 | DUVOGLUSTAT | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL1029 | MIGLUSTAT | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL75971 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL80254 | — | Ki | = | 9700.0 | nM | 5.01 |
| CHEMBL310229 | — | Ki | = | 95000.0 | nM | 4.02 |
| CHEMBL80148 | — | Ki | = | 150000.0 | nM | - |