Assay Detail
Binding
CHEMBL649574
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Inhibition of bovine kidney alpha-L-fucosidase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Convenient synthesis and evaluation of enzyme inhibitory activity of several N-alkyl-, N-phenylalkyl, and cyclic isourea derivatives of 5a-carba-alpha-DL-fucopyranosylamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.73 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314757 | — | — | 1 | 6.96 |
| CHEMBL95106 | — | — | 1 | 6.62 |
| CHEMBL316609 | — | — | 1 | 6.62 |
| CHEMBL95110 | — | — | 1 | 6.57 |
| CHEMBL314772 | DEOXYFUCONOJIRIMYCIN | — | 1 | 6.39 |
| CHEMBL319008 | — | — | 1 | 6.04 |
| CHEMBL96392 | — | — | 1 | 6.00 |
| CHEMBL94486 | — | — | 1 | 5.12 |
| CHEMBL2114287 | — | — | 1 | 5.03 |
| CHEMBL316082 | — | — | 1 | 4.68 |
| CHEMBL2115269 | — | — | 1 | 4.60 |
| CHEMBL317565 | — | — | 1 | 4.14 |
| CHEMBL97066 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314757 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL95106 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL316609 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL95110 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL314772 | DEOXYFUCONOJIRIMYCIN | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL319008 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL96392 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL94486 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL2114287 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL316082 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL2115269 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL317565 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL97066 | — | IC50 | = | 140000.0 | nM | - |