Assay Detail
Binding
CHEMBL649582
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Binding affinity against alpha-L-fucosidase in bovine kidney was determined
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Kidney |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Convenient synthesis and evaluation of enzyme inhibitory activity of several N-alkyl-, N-phenylalkyl, and cyclic isourea derivatives of 5a-carba-alpha-DL-fucopyranosylamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.97 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314757 | — | — | 1 | 7.80 |
| CHEMBL314772 | DEOXYFUCONOJIRIMYCIN | — | 1 | 7.51 |
| CHEMBL316609 | — | — | 1 | 7.50 |
| CHEMBL95110 | — | — | 1 | 7.32 |
| CHEMBL96392 | — | — | 1 | 7.16 |
| CHEMBL319008 | — | — | 1 | 7.13 |
| CHEMBL95106 | — | — | 1 | 6.96 |
| CHEMBL316082 | — | — | 1 | 6.75 |
| CHEMBL2114287 | — | — | 1 | 6.00 |
| CHEMBL2115269 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314757 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL314772 | DEOXYFUCONOJIRIMYCIN | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL316609 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL95110 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL96392 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL319008 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL95106 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL316082 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL2114287 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL2115269 | — | Ki | = | 2900.0 | nM | 5.54 |