Assay Detail
Functional
CHEMBL649618
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of murine B16 Melanoma cell proliferation
12
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.41 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370100 | REBECCAMYCIN | — | 1 | 6.32 |
| CHEMBL326711 | — | — | 3 | 6.28 |
| CHEMBL3350558 | — | — | 1 | 6.21 |
| CHEMBL3350560 | — | — | 1 | 5.97 |
| CHEMBL332728 | — | — | 3 | 5.60 |
| CHEMBL117114 | — | — | 2 | 5.43 |
| CHEMBL3350557 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370100 | REBECCAMYCIN | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL326711 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3350558 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3350560 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL332728 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL326711 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL117114 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL117114 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL326711 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3350557 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL332728 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL332728 | — | IC50 | = | 78000.0 | nM | 4.11 |