Assay Detail
Functional
CHEMBL649619
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In vitro cytotoxic activity required to inhibit murine melanoma B16 cell line
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
A new generation of N-aryl-N'-(1-alkyl-2-chloroethyl)ureas as microtubule disrupters: synthesis, antiproliferative activity, and beta-tubulin alkylation kinetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 4.81 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423394 | — | — | 1 | 5.68 |
| CHEMBL148361 | — | — | 1 | 5.64 |
| CHEMBL145811 | — | — | 1 | 5.38 |
| CHEMBL150008 | — | — | 1 | 5.35 |
| CHEMBL356033 | — | — | 1 | 5.33 |
| CHEMBL358165 | — | — | 1 | 5.30 |
| CHEMBL148690 | — | — | 1 | 5.20 |
| CHEMBL146303 | — | — | 1 | 5.10 |
| CHEMBL149179 | — | — | 1 | 5.07 |
| CHEMBL423213 | — | — | 1 | 5.03 |
| CHEMBL435623 | — | — | 1 | 4.96 |
| CHEMBL357489 | — | — | 1 | 4.80 |
| CHEMBL146242 | — | — | 1 | 4.70 |
| CHEMBL344111 | — | — | 1 | 4.57 |
| CHEMBL146613 | — | — | 1 | 4.57 |
| CHEMBL148438 | — | — | 1 | 4.57 |
| CHEMBL149176 | — | — | 1 | 4.52 |
| CHEMBL358809 | — | — | 1 | 4.48 |
| CHEMBL148563 | — | — | 1 | 4.48 |
| CHEMBL149180 | — | — | 1 | 4.46 |
| CHEMBL434698 | — | — | 1 | 4.34 |
| CHEMBL149267 | — | — | 1 | 4.34 |
| CHEMBL356185 | — | — | 1 | 4.31 |
| CHEMBL146600 | — | — | 1 | 4.05 |
| CHEMBL150060 | — | — | 1 | 4.03 |
| CHEMBL146586 | — | — | 1 | - |
| CHEMBL149503 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423394 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL148361 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL145811 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL150008 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL356033 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL358165 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL148690 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL146303 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL149179 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL423213 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL435623 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL357489 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL146242 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL344111 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL146613 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL148438 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL149176 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL358809 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL148563 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL149180 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL434698 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL149267 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL356185 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL146600 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL150060 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL146586 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL149503 | — | IC50 | > | 100000.0 | nM | - |