Assay Detail
Functional
CHEMBL649663
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Stimulated increase in cAMP in CHO cells expressing human beta-3 receptor
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent, selective 3-pyridylethanolamine beta3 adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 7.98 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58241 | — | — | 1 | 8.92 |
| CHEMBL58407 | — | — | 1 | 8.70 |
| CHEMBL294753 | — | — | 1 | 8.62 |
| CHEMBL292598 | — | — | 1 | 8.57 |
| CHEMBL291516 | — | — | 1 | 8.31 |
| CHEMBL418308 | — | — | 1 | 8.30 |
| CHEMBL291306 | — | — | 1 | 8.24 |
| CHEMBL430594 | — | — | 1 | 8.21 |
| CHEMBL293994 | — | — | 1 | 8.15 |
| CHEMBL293577 | — | — | 1 | 8.14 |
| CHEMBL57908 | — | — | 1 | 8.04 |
| CHEMBL58798 | — | — | 1 | 8.02 |
| CHEMBL291593 | — | — | 1 | 8.01 |
| CHEMBL60281 | — | — | 1 | 8.00 |
| CHEMBL61429 | — | — | 1 | 7.92 |
| CHEMBL433248 | — | — | 1 | 7.66 |
| CHEMBL294172 | — | — | 1 | 7.58 |
| CHEMBL59270 | — | — | 1 | 7.48 |
| CHEMBL294492 | — | — | 1 | 7.40 |
| CHEMBL61962 | — | — | 1 | 7.35 |
| CHEMBL291594 | — | — | 1 | 7.35 |
| CHEMBL294849 | — | — | 1 | 7.30 |
| CHEMBL291992 | — | — | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58241 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL58407 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL294753 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL292598 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL291516 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL418308 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL291306 | — | EC50 | = | 5.8 | nM | 8.24 |
| CHEMBL430594 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL293994 | — | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL293577 | — | EC50 | = | 7.3 | nM | 8.14 |
| CHEMBL57908 | — | EC50 | = | 9.1 | nM | 8.04 |
| CHEMBL58798 | — | EC50 | = | 9.5 | nM | 8.02 |
| CHEMBL291593 | — | EC50 | = | 9.8 | nM | 8.01 |
| CHEMBL60281 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL61429 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL433248 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL294172 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL59270 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL294492 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL61962 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL291594 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL294849 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL291992 | — | EC50 | = | 51.0 | nM | 7.29 |