Assay Detail
Functional
CHEMBL649804
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for its ability to antagonize epinephrine induced primary wave aggregation in human platelets at alpha-2A-adrenergic receptor sites.
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A structure-activity relationship study of benzylic modifications of 4-[1-(1-naphthyl)ethyl]-1H-imidazoles on alpha 1- and alpha 2-adrenergic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.17 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL306751 | — | — | 3 | 5.89 |
| CHEMBL544765 | — | — | 1 | 5.52 |
| CHEMBL77921 | MEDETOMIDINE | 3.0 | 1 | 5.47 |
| CHEMBL542155 | — | — | 1 | 4.21 |
| CHEMBL553835 | — | — | 1 | - |
| CHEMBL75022 | — | — | 1 | - |
| CHEMBL541302 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL306751 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL544765 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL77921 | MEDETOMIDINE | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL306751 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL306751 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL542155 | — | IC50 | = | 61900.0 | nM | 4.21 |
| CHEMBL553835 | — | IC50 | = | 379800.0 | nM | - |
| CHEMBL75022 | — | IC50 | = | 580400.0 | nM | - |
| CHEMBL541302 | — | IC50 | > | 300000.0 | nM | - |