Assay Detail
Binding
CHEMBL649910
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In vitro inhibitory concentration against AT2 receptor from human adrenal tissues.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Potent triazolinone-based angiotensin II receptor antagonists with equivalent affinity for both the AT1 and AT2 subtypes
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.72 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313868 | — | — | 1 | 8.62 |
| CHEMBL321313 | — | — | 1 | 8.59 |
| CHEMBL323506 | — | — | 1 | 7.92 |
| CHEMBL321531 | — | — | 1 | 7.77 |
| CHEMBL96314 | — | — | 1 | 6.85 |
| CHEMBL96554 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313868 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL321313 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL323506 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL321531 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL96314 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL96554 | — | IC50 | = | 270.0 | nM | 6.57 |