Assay Detail
Binding
CHEMBL649912
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for 50% inhibition of [125I]- AII binding to rabbit uterus membrane preparation (AT2)
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Uterus |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Balanced AT1 and AT2 angiotensin II antagonists. III. potent and orally active 5--ketosulfoxide imidazolyl biphenyl sulfonylureas
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.06 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431853 | — | — | 1 | 9.10 |
| CHEMBL87091 | — | — | 1 | 9.00 |
| CHEMBL87244 | — | — | 2 | 8.85 |
| CHEMBL84908 | — | — | 1 | 8.82 |
| CHEMBL315236 | — | — | 1 | 8.77 |
| CHEMBL328985 | — | — | 1 | 8.68 |
| CHEMBL433010 | — | — | 1 | 8.57 |
| CHEMBL264304 | — | — | 1 | 8.55 |
| CHEMBL89032 | — | — | 1 | 8.52 |
| CHEMBL313598 | — | — | 1 | 8.46 |
| CHEMBL312990 | — | — | 1 | 8.40 |
| CHEMBL91046 | — | — | 1 | 8.24 |
| CHEMBL316402 | — | — | 1 | 8.15 |
| CHEMBL315275 | — | — | 1 | 8.09 |
| CHEMBL91047 | — | — | 1 | 7.82 |
| CHEMBL84795 | — | — | 1 | 7.77 |
| CHEMBL86538 | — | — | 1 | 7.52 |
| CHEMBL327297 | — | — | 1 | 7.03 |
| CHEMBL85075 | — | — | 1 | 6.96 |
| CHEMBL327927 | — | — | 1 | 6.94 |
| CHEMBL89772 | — | — | 1 | 6.75 |
| CHEMBL80370 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431853 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL87091 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL87244 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL84908 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL315236 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL328985 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL433010 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL264304 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL89032 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL313598 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL312990 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL87244 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL91046 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL316402 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL315275 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL91047 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL84795 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL86538 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL327297 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL85075 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL327927 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL89772 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL80370 | — | IC50 | = | 920.0 | nM | 6.04 |