Assay Detail
Binding
CHEMBL649913
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Midbrain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent triazolinone-based angiotensin II receptor antagonists with equivalent affinity for both the AT1 and AT2 subtypes
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 8.63 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321313 | — | — | 1 | 10.00 |
| CHEMBL313868 | — | — | 1 | 9.82 |
| CHEMBL321531 | — | — | 1 | 9.82 |
| CHEMBL323506 | — | — | 1 | 9.62 |
| CHEMBL302102 | — | — | 1 | 9.15 |
| CHEMBL276674 | — | — | 1 | 9.00 |
| CHEMBL96075 | — | — | 1 | 8.80 |
| CHEMBL93907 | — | — | 1 | 8.60 |
| CHEMBL96314 | — | — | 1 | 8.46 |
| CHEMBL319730 | — | — | 1 | 8.46 |
| CHEMBL92533 | — | — | 1 | 8.38 |
| CHEMBL94793 | — | — | 1 | 8.31 |
| CHEMBL96554 | — | — | 1 | 8.09 |
| CHEMBL329679 | — | — | 1 | 7.92 |
| CHEMBL265797 | — | — | 1 | 7.92 |
| CHEMBL316299 | — | — | 1 | 7.85 |
| CHEMBL292150 | — | — | 1 | 7.77 |
| CHEMBL316300 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321313 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL313868 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL321531 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL323506 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL302102 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL276674 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL96075 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL93907 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL96314 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL319730 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL92533 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL94793 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL96554 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL329679 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL265797 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL316299 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL292150 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL316300 | — | IC50 | = | 36.0 | nM | 7.44 |