Assay Detail
Binding
CHEMBL649915
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In vitro binding affinity determined against angiotensin II AT2 receptor in rat adrenal medulla preparation
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Adrenal medulla |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4,5-Dihydro-4-oxo-3H-imidazo[4,5-c]pyridines: potent arylacetic acid-derived AT1 antagonists with improved affinity for the AT2 receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.71 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88170 | — | — | 1 | 7.50 |
| CHEMBL88600 | — | — | 1 | 7.33 |
| CHEMBL314603 | — | — | 1 | 7.24 |
| CHEMBL261981 | — | — | 1 | 7.24 |
| CHEMBL91465 | — | — | 1 | 7.16 |
| CHEMBL420607 | — | — | 1 | 7.02 |
| CHEMBL313691 | — | — | 1 | 7.00 |
| CHEMBL314605 | — | — | 1 | 6.92 |
| CHEMBL92479 | — | — | 1 | 6.90 |
| CHEMBL90663 | — | — | 1 | 6.85 |
| CHEMBL88663 | — | — | 1 | 6.82 |
| CHEMBL329655 | — | — | 1 | 6.82 |
| CHEMBL315483 | — | — | 1 | 6.82 |
| CHEMBL92206 | — | — | 1 | 6.78 |
| CHEMBL329887 | — | — | 1 | 6.66 |
| CHEMBL316063 | — | — | 1 | 6.60 |
| CHEMBL328780 | — | — | 1 | 6.52 |
| CHEMBL313142 | — | — | 1 | 6.52 |
| CHEMBL315302 | — | — | 1 | 6.50 |
| CHEMBL315400 | — | — | 1 | 6.44 |
| CHEMBL431592 | — | — | 1 | 6.37 |
| CHEMBL315401 | — | — | 1 | 6.24 |
| CHEMBL328340 | — | — | 1 | 6.02 |
| CHEMBL265291 | — | — | 1 | 4.77 |
| CHEMBL995 | LOSARTAN POTASSIUM | 4.0 | 1 | - |
| CHEMBL89161 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88170 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL88600 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL314603 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL261981 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL91465 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL420607 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL313691 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL314605 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL92479 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL90663 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL88663 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL329655 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL315483 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL92206 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL329887 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL316063 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL328780 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL313142 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL315302 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL315400 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL431592 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL315401 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL328340 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL265291 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL995 | LOSARTAN POTASSIUM | IC50 | > | 10000.0 | nM | - |
| CHEMBL89161 | — | IC50 | > | 10000.0 | nM | - |