Assay Detail
Binding
CHEMBL649916
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In vitro binding affinity for angiotensin II AT2 receptor in rat midbrain
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.04 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL335778 | — | — | 1 | 5.75 |
| CHEMBL336180 | — | — | 1 | 5.62 |
| CHEMBL293511 | — | — | 1 | 5.54 |
| CHEMBL131156 | — | — | 1 | 5.44 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 4.30 |
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | — | 1 | 4.30 |
| CHEMBL7550 | L-158809 | — | 1 | 4.30 |
| CHEMBL334670 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL335778 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL336180 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL293511 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL131156 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL191 | LOSARTAN | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL7550 | L-158809 | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL334670 | — | IC50 | > | 10000.0 | nM | - |