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Assay Detail

CHEMBL650036

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against Agrobacterium sp. Beta-glucosidase employing fluorescence spectrometric method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Agrobacterium
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Lysosomal acid glucosylceramidase (CHEMBL2179)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Powerful probes for glycosidases: novel, fluorescently tagged glycosidase inhibitors.
Hermetter A, Scholze H, Stütz AE, Withers SG, Wrodnigg TM.
Bioorg Med Chem Lett (2001) 11 : 1339 -1342
PubMed 11392550 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 5 7.58 8.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3349997 1 8.68
CHEMBL3349996 1 8.62
CHEMBL3350086 1 7.60
CHEMBL469844 1 6.70
CHEMBL27943 1 6.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3349997 Ki = 2.1 nM 8.68
CHEMBL3349996 Ki = 2.4 nM 8.62
CHEMBL3350086 Ki = 25.0 nM 7.60
CHEMBL469844 Ki = 200.0 nM 6.70
CHEMBL27943 Ki = 500.0 nM 6.30