Assay Detail
Functional
CHEMBL650141
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Inhibition of murine B16 melanoma cell proliferation measured by the MTT assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of 9-O-substituted derivatives of 9-hydroxy-5, 6-dimethyl-6H-pyrido[4,3-b]carbazole-1-carboxylic acid (2-(dimethylamino)ethyl)amide and their 10- and 11-methyl analogues with improved antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 7.39 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423492 | — | — | 1 | 9.70 |
| CHEMBL69345 | — | — | 1 | 8.85 |
| CHEMBL306455 | — | — | 1 | 8.64 |
| CHEMBL304371 | — | — | 1 | 8.52 |
| CHEMBL308970 | — | — | 1 | 8.51 |
| CHEMBL70069 | — | — | 1 | 8.49 |
| CHEMBL68140 | — | — | 1 | 8.47 |
| CHEMBL69834 | — | — | 1 | 8.43 |
| CHEMBL302570 | — | — | 1 | 8.40 |
| CHEMBL305006 | — | — | 1 | 8.39 |
| CHEMBL68631 | — | — | 1 | 8.32 |
| CHEMBL68714 | — | — | 1 | 8.30 |
| CHEMBL303482 | — | — | 1 | 8.27 |
| CHEMBL431959 | — | — | 1 | 8.24 |
| CHEMBL71238 | — | — | 1 | 8.21 |
| CHEMBL422949 | — | — | 1 | 8.20 |
| CHEMBL71481 | — | — | 1 | 8.19 |
| CHEMBL307570 | — | — | 1 | 8.15 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.12 |
| CHEMBL303440 | — | — | 1 | 8.00 |
| CHEMBL449656 | — | — | 1 | 7.85 |
| CHEMBL69534 | — | — | 1 | 7.85 |
| CHEMBL303011 | — | — | 1 | 7.83 |
| CHEMBL69485 | — | — | 1 | 7.68 |
| CHEMBL70768 | — | — | 1 | 7.65 |
| CHEMBL68154 | — | — | 1 | 7.53 |
| CHEMBL71560 | — | — | 1 | 7.34 |
| CHEMBL52837 | — | — | 1 | 7.23 |
| CHEMBL419249 | — | — | 1 | 7.10 |
| CHEMBL16699 | ELLIPTINIUM | 2.0 | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423492 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL69345 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL306455 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL304371 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL308970 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL70069 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL68140 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL69834 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL302570 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL305006 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL68631 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL68714 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL303482 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL431959 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL71238 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL422949 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL71481 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL307570 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL303440 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL449656 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL69534 | — | IC50 | = | 14.1 | nM | 7.85 |
| CHEMBL303011 | — | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL69485 | — | IC50 | = | 20.8 | nM | 7.68 |
| CHEMBL70768 | — | IC50 | = | 22.3 | nM | 7.65 |
| CHEMBL68154 | — | IC50 | = | 29.4 | nM | 7.53 |
| CHEMBL71560 | — | IC50 | = | 45.7 | nM | 7.34 |
| CHEMBL52837 | — | IC50 | = | 58.4 | nM | 7.23 |
| CHEMBL419249 | — | IC50 | = | 78.7 | nM | 7.10 |
| CHEMBL16699 | ELLIPTINIUM | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL69533 | — | IC50 | = | 195.3 | nM | 6.71 |
| CHEMBL72943 | — | IC50 | = | 279.3 | nM | 6.55 |
| CHEMBL72944 | — | IC50 | = | 333.6 | nM | 6.48 |
| CHEMBL70862 | — | IC50 | = | 511.0 | nM | 6.29 |
| CHEMBL71350 | — | IC50 | = | 589.9 | nM | 6.23 |
| CHEMBL304740 | — | IC50 | = | 782.1 | nM | 6.11 |
| CHEMBL71622 | — | IC50 | = | 954.5 | nM | 6.02 |
| CHEMBL307997 | — | IC50 | = | 1374.0 | nM | 5.86 |
| CHEMBL68383 | — | IC50 | = | 1766.5 | nM | 5.75 |
| CHEMBL69600 | — | IC50 | = | 2299.5 | nM | 5.64 |
| CHEMBL302358 | — | IC50 | = | 2471.3 | nM | 5.61 |
| CHEMBL303025 | — | IC50 | = | 2666.7 | nM | 5.57 |
| CHEMBL70664 | — | IC50 | = | 2689.0 | nM | 5.57 |
| CHEMBL308240 | — | IC50 | = | 3256.0 | nM | 5.49 |
| CHEMBL68655 | — | IC50 | = | 3466.0 | nM | 5.46 |