Assay Detail
Binding
CHEMBL650155
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Compound was tested for inhibition of Angiotensin II receptor in rabbit aorta binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
New potent angiotensin II receptor antagonists containing phenylthiophenes and phenylfurans in place of the biphenyl moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.73 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58156 | — | — | 1 | 8.64 |
| CHEMBL274626 | — | — | 1 | 8.62 |
| CHEMBL14229 | — | — | 1 | 7.64 |
| CHEMBL280075 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58156 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL274626 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL14229 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL280075 | — | IC50 | = | 1000.0 | nM | 6.00 |