Assay Detail
Binding
CHEMBL650168
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Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
4-(Heteroarylthio)-2-biphenylyltetrazoles as nonpeptide angiotensin II antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.80 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.34 |
| CHEMBL141019 | — | — | 1 | 7.70 |
| CHEMBL142380 | — | — | 1 | 7.51 |
| CHEMBL142860 | — | — | 1 | 7.02 |
| CHEMBL423370 | — | — | 1 | 6.57 |
| CHEMBL142409 | — | — | 1 | 6.46 |
| CHEMBL141447 | — | — | 1 | 6.43 |
| CHEMBL341724 | — | — | 1 | 5.82 |
| CHEMBL358791 | — | — | 1 | 5.33 |
| CHEMBL358044 | — | — | 1 | - |
| CHEMBL142300 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191 | LOSARTAN | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL141019 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL142380 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL142860 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL423370 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL142409 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL141447 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL341724 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL358791 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL358044 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL142300 | — | IC50 | > | 10000.0 | nM | - |