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Assay Detail

CHEMBL650169

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Binding
Inhibitory activity of compound against HIV-1 aspartyl protease.
ChEMBL ↗
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus 1
Confidence 9 — Direct single protein target
Curated By Expert

Target

Human immunodeficiency virus type 1 protease (CHEMBL243) ↗
Type SINGLE PROTEIN
Organism Human immunodeficiency virus 1

Publication

Six-membered cyclic ureas as HIV-1 protease inhibitors: a QSAR study based on CODESSA PRO approach. Quantitative structure-activity relationships.
Katritzky AR, Oliferenko A, Lomaka A, Karelson M.
Bioorg Med Chem Lett (2002) 12 : 3453 -3457
PubMed 12419382 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 51 9.07 11.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL36900 — — 1 11.00
CHEMBL284942 — — 1 10.70
CHEMBL288254 — — 1 10.70
CHEMBL416783 — — 1 10.70
CHEMBL116517 — — 1 10.70
CHEMBL291004 — — 1 10.52
CHEMBL324293 — — 1 10.52
CHEMBL290331 — — 1 10.22
CHEMBL366576 — — 1 10.22
CHEMBL416612 — — 1 10.22
CHEMBL290362 — — 1 10.10
CHEMBL113884 — — 1 10.10
CHEMBL284340 — — 1 10.04
CHEMBL446395 — — 1 10.00
CHEMBL37593 — — 1 10.00
CHEMBL264852 — — 1 10.00
CHEMBL290254 — — 1 10.00
CHEMBL290074 — — 1 9.89
CHEMBL288261 — — 1 9.82
CHEMBL286159 — — 1 9.62
CHEMBL286390 — — 1 9.60
CHEMBL36581 — — 1 9.55
CHEMBL284941 — — 1 9.51
CHEMBL36437 — — 1 9.42
CHEMBL432093 — — 1 9.39
CHEMBL287923 — — 1 9.32
CHEMBL285871 — — 1 9.31
CHEMBL431321 — — 1 9.19
CHEMBL287546 — — 1 9.06
CHEMBL286693 — — 1 9.04

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL36900 — Ki = 0.01 nM 11.00
CHEMBL284942 — Ki = 0.02004 nM 10.70
CHEMBL116517 — Ki = 0.02004 nM 10.70
CHEMBL288254 — Ki = 0.02004 nM 10.70
CHEMBL416783 — Ki = 0.02004 nM 10.70
CHEMBL291004 — Ki = 0.03006 nM 10.52
CHEMBL324293 — Ki = 0.03006 nM 10.52
CHEMBL290331 — Ki = 0.06012 nM 10.22
CHEMBL366576 — Ki = 0.06012 nM 10.22
CHEMBL416612 — Ki = 0.06012 nM 10.22
CHEMBL290362 — Ki = 0.08017 nM 10.10
CHEMBL113884 — Ki = 0.08017 nM 10.10
CHEMBL284340 — Ki = 0.09016 nM 10.04
CHEMBL264852 — Ki = 0.1 nM 10.00
CHEMBL37593 — Ki = 0.1 nM 10.00
CHEMBL446395 — Ki = 0.1 nM 10.00
CHEMBL290254 — Ki = 0.1 nM 10.00
CHEMBL290074 — Ki = 0.13 nM 9.89
CHEMBL288261 — Ki = 0.1503 nM 9.82
CHEMBL286159 — Ki = 0.2404 nM 9.62
CHEMBL286390 — Ki = 0.25 nM 9.60
CHEMBL36581 — Ki = 0.2805 nM 9.55
CHEMBL284941 — Ki = 0.3105 nM 9.51
CHEMBL36437 — Ki = 0.3802 nM 9.42
CHEMBL432093 — Ki = 0.4102 nM 9.39
CHEMBL287923 — Ki = 0.4808 nM 9.32
CHEMBL285871 — Ki = 0.4909 nM 9.31
CHEMBL431321 — Ki = 0.6501 nM 9.19
CHEMBL287546 — Ki = 0.871 nM 9.06
CHEMBL286693 — Ki = 0.912 nM 9.04
CHEMBL37472 — Ki = 1.202 nM 8.92
CHEMBL289907 — Ki = 1.403 nM 8.85
CHEMBL289393 — Ki = 1.603 nM 8.79
CHEMBL36862 — Ki = 1.702 nM 8.77
CHEMBL36939 — Ki = 2.6 nM 8.59
CHEMBL420503 — Ki = 4.909 nM 8.31
CHEMBL38281 — Ki = 5.61 nM 8.25
CHEMBL286794 — Ki = 6.209 nM 8.21
CHEMBL39592 — Ki = 8.017 nM 8.10
CHEMBL38339 — Ki = 10.99 nM 7.96
CHEMBL37701 — Ki = 14.03 nM 7.85
CHEMBL37083 — Ki = 14.0 nM 7.85
CHEMBL37639 — Ki = 15.03 nM 7.82
CHEMBL289934 — Ki = 33.04 nM 7.48
CHEMBL287520 — Ki = 40.09 nM 7.40
CHEMBL37618 — Ki = 44.06 nM 7.36
CHEMBL288239 — Ki = 66.07 nM 7.18
CHEMBL287818 — Ki = 110.15 nM 6.96
CHEMBL288513 — Ki = 157.04 nM 6.80
CHEMBL286304 — Ki = 230.14 nM 6.64