Assay Detail
Functional
CHEMBL650229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
alpha(1)-Adrenoceptor agonists: the identification of novel alpha(1A )subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 30 | 8.01 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422477 | — | — | 1 | 9.60 |
| CHEMBL142784 | — | — | 1 | 9.30 |
| CHEMBL143801 | — | — | 1 | 9.00 |
| CHEMBL279136 | — | — | 1 | 8.90 |
| CHEMBL357129 | — | — | 1 | 8.90 |
| CHEMBL356605 | — | — | 1 | 8.70 |
| CHEMBL143973 | — | — | 1 | 8.60 |
| CHEMBL142871 | — | — | 1 | 8.60 |
| CHEMBL13789 | — | — | 1 | 8.50 |
| CHEMBL143562 | — | — | 1 | 8.50 |
| CHEMBL142387 | — | — | 1 | 8.30 |
| CHEMBL344551 | — | — | 1 | 8.30 |
| CHEMBL337862 | — | — | 1 | 8.10 |
| CHEMBL341747 | — | — | 1 | 7.90 |
| CHEMBL13852 | CIRAZOLINE | 2.0 | 1 | 7.90 |
| CHEMBL420683 | — | — | 1 | 7.90 |
| CHEMBL344957 | — | — | 1 | 7.60 |
| CHEMBL142958 | — | — | 1 | 7.60 |
| CHEMBL421011 | — | — | 1 | 7.50 |
| CHEMBL142967 | — | — | 1 | 7.40 |
| CHEMBL142864 | — | — | 1 | 7.00 |
| CHEMBL342324 | — | — | 1 | 6.90 |
| CHEMBL143766 | — | — | 1 | 6.80 |
| CHEMBL72958 | NS-49 | — | 1 | 6.50 |
| CHEMBL358802 | — | — | 1 | 5.90 |
| CHEMBL344294 | — | — | 1 | - |
| CHEMBL144956 | — | — | 1 | - |
| CHEMBL142310 | — | — | 1 | - |
| CHEMBL141986 | — | — | 1 | - |
| CHEMBL117914 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422477 | — | EC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL142784 | — | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL143801 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL279136 | — | EC50 | = | 1.259 | nM | 8.90 |
| CHEMBL357129 | — | EC50 | = | 1.259 | nM | 8.90 |
| CHEMBL356605 | — | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL143973 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL142871 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL13789 | — | EC50 | = | 3.162 | nM | 8.50 |
| CHEMBL143562 | — | EC50 | = | 3.162 | nM | 8.50 |
| CHEMBL142387 | — | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL344551 | — | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL337862 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL341747 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL13852 | CIRAZOLINE | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL420683 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL344957 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL142958 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL421011 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL142967 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL142864 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL342324 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL143766 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL72958 | NS-49 | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL358802 | — | EC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL344294 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL144956 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL142310 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL141986 | — | EC50 | < | 100000.0 | nM | - |
| CHEMBL117914 | — | EC50 | < | 5011.87 | nM | - |