Assay Detail
Functional
CHEMBL650231
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 31 | 7.78 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL152155 | — | — | 1 | 9.33 |
| CHEMBL155326 | — | — | 1 | 9.18 |
| CHEMBL414185 | — | — | 1 | 9.10 |
| CHEMBL155327 | — | — | 1 | 9.10 |
| CHEMBL152693 | — | — | 1 | 9.07 |
| CHEMBL346380 | — | — | 1 | 8.65 |
| CHEMBL152725 | — | — | 1 | 8.57 |
| CHEMBL156950 | — | — | 1 | 8.48 |
| CHEMBL434074 | — | — | 1 | 8.35 |
| CHEMBL349082 | — | — | 1 | 8.34 |
| CHEMBL154298 | — | — | 1 | 8.17 |
| CHEMBL156661 | — | — | 1 | 8.00 |
| CHEMBL13852 | CIRAZOLINE | 2.0 | 1 | 7.90 |
| CHEMBL154023 | — | — | 1 | 7.82 |
| CHEMBL117381 | — | — | 1 | 7.76 |
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 1 | 7.70 |
| CHEMBL356195 | — | — | 1 | 7.68 |
| CHEMBL154170 | — | — | 1 | 7.61 |
| CHEMBL351543 | — | — | 1 | 7.44 |
| CHEMBL347268 | — | — | 1 | 7.41 |
| CHEMBL156893 | — | — | 1 | 7.37 |
| CHEMBL154346 | — | — | 1 | 7.34 |
| CHEMBL351542 | — | — | 1 | 7.29 |
| CHEMBL346465 | — | — | 1 | 7.28 |
| CHEMBL761 | NAPHAZOLINE | 4.0 | 1 | 7.20 |
| CHEMBL439822 | — | — | 1 | 7.06 |
| CHEMBL352225 | — | — | 1 | 6.96 |
| CHEMBL152154 | — | — | 1 | 6.49 |
| CHEMBL347920 | — | — | 1 | 6.18 |
| CHEMBL350906 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL152155 | — | EC50 | = | 0.4677 | nM | 9.33 |
| CHEMBL155326 | — | EC50 | = | 0.6607 | nM | 9.18 |
| CHEMBL414185 | — | EC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL155327 | — | EC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL152693 | — | EC50 | = | 0.8511 | nM | 9.07 |
| CHEMBL346380 | — | EC50 | = | 2.239 | nM | 8.65 |
| CHEMBL152725 | — | EC50 | = | 2.692 | nM | 8.57 |
| CHEMBL156950 | — | EC50 | = | 3.311 | nM | 8.48 |
| CHEMBL434074 | — | EC50 | = | 4.467 | nM | 8.35 |
| CHEMBL349082 | — | EC50 | = | 4.571 | nM | 8.34 |
| CHEMBL154298 | — | EC50 | = | 6.761 | nM | 8.17 |
| CHEMBL156661 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL13852 | CIRAZOLINE | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL154023 | — | EC50 | = | 15.14 | nM | 7.82 |
| CHEMBL117381 | — | EC50 | = | 17.38 | nM | 7.76 |
| CHEMBL762 | OXYMETAZOLINE | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL356195 | — | EC50 | = | 20.89 | nM | 7.68 |
| CHEMBL154170 | — | EC50 | = | 24.55 | nM | 7.61 |
| CHEMBL351543 | — | EC50 | = | 36.31 | nM | 7.44 |
| CHEMBL347268 | — | EC50 | = | 38.9 | nM | 7.41 |
| CHEMBL156893 | — | EC50 | = | 42.66 | nM | 7.37 |
| CHEMBL154346 | — | EC50 | = | 45.71 | nM | 7.34 |
| CHEMBL351542 | — | EC50 | = | 51.29 | nM | 7.29 |
| CHEMBL346465 | — | EC50 | = | 52.48 | nM | 7.28 |
| CHEMBL761 | NAPHAZOLINE | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL439822 | — | EC50 | = | 87.1 | nM | 7.06 |
| CHEMBL352225 | — | EC50 | = | 109.65 | nM | 6.96 |
| CHEMBL152154 | — | EC50 | = | 323.59 | nM | 6.49 |
| CHEMBL347920 | — | EC50 | = | 660.69 | nM | 6.18 |
| CHEMBL350906 | — | EC50 | = | 676.08 | nM | 6.17 |
| CHEMBL358685 | — | EC50 | = | 724.44 | nM | 6.14 |