Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL650294

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [125I][Ile5]-AII binding to bovine adrenal cortex membrane Angiotensin II receptor type 1
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Tissue Adrenal cortex
Confidence 9 — Direct single protein target
Curated By Expert

Target

Type-1 angiotensin II receptor (CHEMBL3374)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Discovery and development of aryl-fused imidazole-based angiotensin II antagonists
Miyake K, Matsukura M, Yoneda N, Hiroshima O, Mori N, Ishihara H, Musha T, Matsuoka T, Shoji T, Minami N, Hamano S, Saito I
Bioorg Med Chem Lett (1994) 4 : 213 -218
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.25 5.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL308424 1 5.82
CHEMBL306670 1 5.80
CHEMBL65955 1 5.66
CHEMBL70134 1 5.66
CHEMBL69475 1 5.60
CHEMBL306486 1 5.50
CHEMBL68713 1 5.33
CHEMBL71254 1 5.07
CHEMBL70239 1 4.70
CHEMBL69025 1 4.48
CHEMBL303247 1 4.09
CHEMBL303907 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL308424 IC50 = 1500.0 nM 5.82
CHEMBL306670 IC50 = 1600.0 nM 5.80
CHEMBL65955 IC50 = 2200.0 nM 5.66
CHEMBL70134 IC50 = 2200.0 nM 5.66
CHEMBL69475 IC50 = 2500.0 nM 5.60
CHEMBL306486 IC50 = 3200.0 nM 5.50
CHEMBL68713 IC50 = 4700.0 nM 5.33
CHEMBL71254 IC50 = 8500.0 nM 5.07
CHEMBL70239 IC50 = 20000.0 nM 4.70
CHEMBL69025 IC50 = 33000.0 nM 4.48
CHEMBL303247 IC50 = 81000.0 nM 4.09
CHEMBL303907 IC50 > 100000.0 nM -