Assay Detail
Binding
CHEMBL650295
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro for inhibition of [125I]-angiotensin II (0.1 nM) binding to angiotensin II receptor type 1 in membrane fractions of bovine adrenal cortex
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Adrenal cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nonpeptide angiotensin II receptor antagonists: synthesis, biological activities, and structure-activity relationships of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.95 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL447182 | — | — | 1 | 8.31 |
| CHEMBL116094 | — | — | 1 | 8.28 |
| CHEMBL115946 | — | — | 1 | 8.16 |
| CHEMBL1516 | OLMESARTAN | 3.0 | 1 | 8.09 |
| CHEMBL115273 | — | — | 1 | 8.04 |
| CHEMBL320135 | — | — | 1 | 8.02 |
| CHEMBL419762 | — | — | 1 | 7.96 |
| CHEMBL115021 | — | — | 1 | 7.92 |
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | — | 1 | 7.66 |
| CHEMBL113714 | — | — | 1 | 7.55 |
| CHEMBL333155 | — | — | 1 | 7.55 |
| CHEMBL112414 | — | — | 1 | 7.52 |
| CHEMBL114527 | — | — | 1 | 7.43 |
| CHEMBL115206 | — | — | 1 | 7.34 |
| CHEMBL114752 | — | — | 1 | 7.30 |
| CHEMBL116102 | — | — | 1 | 7.29 |
| CHEMBL417366 | — | — | 1 | 7.24 |
| CHEMBL324729 | — | — | 1 | 7.22 |
| CHEMBL116054 | — | — | 1 | 7.00 |
| CHEMBL441649 | — | — | 1 | 7.00 |
| CHEMBL114788 | — | — | 1 | 6.96 |
| CHEMBL115392 | — | — | 1 | 6.96 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 6.92 |
| CHEMBL49170 | — | — | 1 | 6.89 |
| CHEMBL326400 | — | — | 1 | 6.70 |
| CHEMBL115393 | — | — | 1 | 6.57 |
| CHEMBL300186 | — | — | 1 | 6.50 |
| CHEMBL323819 | — | — | 1 | 6.44 |
| CHEMBL274447 | — | — | 1 | 6.31 |
| CHEMBL113040 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL447182 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL116094 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL115946 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL1516 | OLMESARTAN | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL115273 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL320135 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL419762 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL115021 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL907 | CARBOXYLIC ACID METABOLITE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL333155 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL113714 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL112414 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL114527 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL115206 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL114752 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL116102 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL417366 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL324729 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL116054 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL441649 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL114788 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL115392 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL191 | LOSARTAN | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL49170 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL326400 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL115393 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL300186 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL323819 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL274447 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL113040 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL439743 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL52601 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL326086 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL115560 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL53322 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL112637 | — | IC50 | = | 45000.0 | nM | 4.35 |