Assay Detail
Binding
CHEMBL650296
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Concentration that gives 50% inhibition for binding of 125-I-[Sar1, IIe8] angiotensin to Angiotensin II receptor, type 1 in bovine adrenal cortex membrane.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Adrenal cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Substituted pyrrolidin-2-one biphenyltetrazoles as angiotensin II antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.68 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123348 | — | — | 1 | 7.22 |
| CHEMBL121871 | — | — | 1 | 7.22 |
| CHEMBL123713 | — | — | 1 | 7.00 |
| CHEMBL124449 | — | — | 1 | 6.85 |
| CHEMBL421094 | — | — | 1 | 6.60 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 6.37 |
| CHEMBL330866 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123348 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL121871 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL123713 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL124449 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL421094 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL191 | LOSARTAN | IC50 | = | 425.0 | nM | 6.37 |
| CHEMBL330866 | — | IC50 | = | 3100.0 | nM | 5.51 |