Assay Detail
Binding
CHEMBL650297
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Concentration required for 50% inhibition of binding against Angiotensin II receptor, type 1 in bovine adrenal cortex
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Adrenal cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
(6-oxo-3-pyridazinyl)-benzimidazoles as potent angiotensin II receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.65 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25989 | — | — | 1 | 7.66 |
| CHEMBL24550 | — | — | 1 | 6.79 |
| CHEMBL284546 | — | — | 1 | 5.26 |
| CHEMBL26449 | — | — | 1 | 5.16 |
| CHEMBL24646 | PIMOBENDAN | 2.0 | 1 | 4.77 |
| CHEMBL287374 | — | — | 1 | 4.27 |
| CHEMBL286470 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25989 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL24550 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL284546 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL26449 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL24646 | PIMOBENDAN | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL287374 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL286470 | — | IC50 | > | 1000000.0 | nM | - |