Assay Detail
Binding
CHEMBL650301
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [125I]angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL1671613) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
New nonpeptide angiotensin II receptor antagonists. 3. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy)pyridine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.56 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434768 | — | — | 1 | 8.40 |
| CHEMBL432459 | — | — | 1 | 8.30 |
| CHEMBL283742 | — | — | 1 | 8.30 |
| CHEMBL281192 | — | — | 1 | 8.22 |
| CHEMBL280189 | — | — | 1 | 8.22 |
| CHEMBL22879 | — | — | 1 | 8.10 |
| CHEMBL283110 | — | — | 1 | 8.10 |
| CHEMBL21968 | — | — | 1 | 8.05 |
| CHEMBL23006 | — | — | 1 | 7.85 |
| CHEMBL285560 | — | — | 1 | 7.85 |
| CHEMBL142380 | — | — | 1 | 7.80 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.75 |
| CHEMBL283579 | — | — | 1 | 7.64 |
| CHEMBL22945 | — | — | 1 | 7.60 |
| CHEMBL428711 | — | — | 1 | 7.60 |
| CHEMBL22908 | — | — | 1 | 7.52 |
| CHEMBL284536 | — | — | 1 | 7.51 |
| CHEMBL22391 | — | — | 1 | 7.47 |
| CHEMBL22426 | — | — | 1 | 7.30 |
| CHEMBL418226 | — | — | 1 | 7.30 |
| CHEMBL22692 | — | — | 1 | 7.27 |
| CHEMBL283770 | — | — | 1 | 7.07 |
| CHEMBL283372 | — | — | 1 | 6.92 |
| CHEMBL22387 | — | — | 1 | 6.89 |
| CHEMBL22837 | — | — | 1 | 6.72 |
| CHEMBL281999 | — | — | 1 | 6.52 |
| CHEMBL25220 | — | — | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434768 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL432459 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL283742 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL281192 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL280189 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL22879 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL283110 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL21968 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL23006 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL285560 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL142380 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL191 | LOSARTAN | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL283579 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL22945 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL428711 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL22908 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL284536 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL22391 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL22426 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL418226 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL22692 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL283770 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL283372 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL22387 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL22837 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL281999 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL25220 | — | IC50 | = | 1170.0 | nM | 5.93 |