Assay Detail
Binding
CHEMBL650302
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for in vitro inhibition of specific binding of [I-125]AII to Angiotensin II receptor, type 1 in guinea pig adrenal membrane preparation
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL1671613) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
The synthesis and biological activity of tetrahydroquinoline angiotensin II antagonists containing a substituted biphenyltetrazole group
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.50 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418226 | — | — | 1 | 8.30 |
| CHEMBL314982 | — | — | 1 | 8.05 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.75 |
| CHEMBL86604 | — | — | 1 | 7.54 |
| CHEMBL89614 | — | — | 1 | 7.27 |
| CHEMBL86495 | — | — | 1 | 7.17 |
| CHEMBL84792 | — | — | 1 | 7.03 |
| CHEMBL87034 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418226 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL314982 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL191 | LOSARTAN | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL86604 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL89614 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL86495 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL84792 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL87034 | — | IC50 | = | 140.0 | nM | 6.85 |