Assay Detail
Functional
CHEMBL650303
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membrane
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL1671613) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.08 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159096 | — | — | 1 | 8.42 |
| CHEMBL418226 | — | — | 1 | 8.30 |
| CHEMBL284536 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159096 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL418226 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL284536 | — | IC50 | = | 30.0 | nM | 7.52 |