Assay Detail
Binding
CHEMBL650304
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In vitro inhibition of the specific binding of [125I]angiotensin II to a guinea pig adrenal membrane preparation
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Type-1 angiotensin II receptor (CHEMBL1671613) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
New nonpeptide angiotensin II receptor antagonists. 2. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy)quinoline derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.61 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL337017 | — | — | 1 | 7.89 |
| CHEMBL142380 | — | — | 1 | 7.80 |
| CHEMBL995 | LOSARTAN POTASSIUM | 4.0 | 1 | 7.75 |
| CHEMBL128644 | — | — | 1 | 7.66 |
| CHEMBL341210 | — | — | 1 | 7.58 |
| CHEMBL337955 | — | — | 1 | 7.58 |
| CHEMBL284536 | — | — | 1 | 7.51 |
| CHEMBL341223 | — | — | 1 | 7.40 |
| CHEMBL334431 | — | — | 1 | 7.22 |
| CHEMBL129872 | — | — | 1 | 7.18 |
| CHEMBL128389 | — | — | 1 | 7.16 |
| CHEMBL336167 | — | — | 1 | 6.92 |
| CHEMBL130540 | — | — | 1 | 6.85 |
| CHEMBL132509 | — | — | 1 | 6.85 |
| CHEMBL132115 | — | — | 1 | 6.80 |
| CHEMBL339846 | — | — | 1 | 6.77 |
| CHEMBL132269 | — | — | 1 | 6.75 |
| CHEMBL338900 | — | — | 1 | 6.66 |
| CHEMBL423370 | — | — | 1 | 6.57 |
| CHEMBL337446 | — | — | 1 | 6.51 |
| CHEMBL131050 | — | — | 1 | 6.44 |
| CHEMBL141447 | — | — | 1 | 6.43 |
| CHEMBL274447 | — | — | 1 | 6.37 |
| CHEMBL337380 | — | — | 1 | 6.34 |
| CHEMBL130455 | — | — | 1 | 6.33 |
| CHEMBL338048 | — | — | 1 | 6.22 |
| CHEMBL434615 | — | — | 1 | 6.07 |
| CHEMBL128397 | — | — | 1 | 6.02 |
| CHEMBL130275 | — | — | 1 | 5.92 |
| CHEMBL336056 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL337017 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL142380 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL995 | LOSARTAN POTASSIUM | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL128644 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL341210 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL337955 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL284536 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL341223 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL334431 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL129872 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL128389 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL336167 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL130540 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL132509 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL132115 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL339846 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL132269 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL338900 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL423370 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL337446 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL131050 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL141447 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL274447 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL337380 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL130455 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL338048 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL434615 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL128397 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL130275 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL336056 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL129194 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL128332 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL128536 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL339592 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL130858 | — | IC50 | = | 90000.0 | nM | 4.05 |