Assay Detail
Binding
CHEMBL650353
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In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
PD 176252--the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.59 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413196 | — | — | 1 | 10.40 |
| CHEMBL437027 | BOMBESIN | 1.0 | 1 | 9.82 |
| CHEMBL314375 | — | — | 1 | 9.15 |
| CHEMBL312926 | — | — | 1 | 8.43 |
| CHEMBL85291 | — | — | 1 | 8.24 |
| CHEMBL327388 | — | — | 1 | 8.19 |
| CHEMBL433143 | — | — | 1 | 8.05 |
| CHEMBL329650 | — | — | 1 | 7.77 |
| CHEMBL87846 | — | — | 1 | 7.50 |
| CHEMBL85400 | — | — | 1 | 7.48 |
| CHEMBL313030 | — | — | 1 | 7.46 |
| CHEMBL327840 | — | — | 1 | 7.43 |
| CHEMBL403317 | — | — | 1 | 7.25 |
| CHEMBL313346 | — | — | 1 | 7.07 |
| CHEMBL327678 | — | — | 1 | 7.07 |
| CHEMBL86370 | — | — | 1 | 7.05 |
| CHEMBL90614 | — | — | 1 | 6.91 |
| CHEMBL316085 | — | — | 1 | 6.83 |
| CHEMBL88010 | — | — | 1 | 6.56 |
| CHEMBL89734 | — | — | 1 | 6.39 |
| CHEMBL87079 | — | — | 1 | 5.96 |
| CHEMBL89813 | — | — | 1 | 5.90 |
| CHEMBL86828 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413196 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL437027 | BOMBESIN | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL314375 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL312926 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL85291 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL327388 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL433143 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL329650 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL87846 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL85400 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL313030 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL327840 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL403317 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL313346 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL327678 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL86370 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL90614 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL316085 | — | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL88010 | — | Ki | = | 273.0 | nM | 6.56 |
| CHEMBL89734 | — | Ki | = | 404.0 | nM | 6.39 |
| CHEMBL87079 | — | Ki | = | 1096.0 | nM | 5.96 |
| CHEMBL89813 | — | Ki | = | 1254.0 | nM | 5.90 |
| CHEMBL86828 | — | Ki | > | 10000.0 | nM | - |