Assay Detail
Functional
CHEMBL650358
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro growth factor-dependent proliferation against murine bone marrow cell was determined
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Osteoclast-like |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and in vitro cytotoxicity of diastereoisomerically modified dolastatin 15 analogues
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.35 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35769 | DOLASTATIN 15 | — | 1 | 7.77 |
| CHEMBL3350145 | — | — | 2 | 7.40 |
| CHEMBL3350146 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35769 | DOLASTATIN 15 | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3350145 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3350145 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3350146 | — | IC50 | = | 120.0 | nM | 6.92 |