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Assay Detail

CHEMBL650512

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory activity against HIV-111B in C8166 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type C8166
Confidence 1 — Organism
Curated By Intermediate

Target

C8166 (CHEMBL614533)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and HIV-1 inhibition of novel benzimidazole derivatives
Gardiner JM, Loyns CR, Burke A, Khan A, Mahmood N
Bioorg Med Chem Lett (1995) 5 : 1251 -1254
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 9 6.16 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL293498 1 8.70
CHEMBL129 ZIDOVUDINE 4.0 1 7.80
CHEMBL23036 1 6.22
CHEMBL277492 1 5.80
CHEMBL25543 1 5.70
CHEMBL22780 1 5.50
CHEMBL22127 1 5.40
CHEMBL25496 1 5.22
CHEMBL22644 1 5.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL293498 EC50 = 2.0 nM 8.70
CHEMBL129 ZIDOVUDINE EC50 = 16.0 nM 7.80
CHEMBL23036 EC50 = 600.0 nM 6.22
CHEMBL277492 EC50 = 1600.0 nM 5.80
CHEMBL25543 EC50 = 2000.0 nM 5.70
CHEMBL22780 EC50 = 3200.0 nM 5.50
CHEMBL22127 EC50 = 4000.0 nM 5.40
CHEMBL25496 EC50 = 6000.0 nM 5.22
CHEMBL22644 EC50 = 8000.0 nM 5.10