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Assay Detail

CHEMBL650514

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Tested against HIV-1 111B for Inhibition of viral replication by determining reduction of syncytia formation and antigen gp120 in C8166 cells, estimated by ELISA; value ranges from 0.6-6 uM
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type C8166
Confidence 1 — Organism
Curated By Intermediate

Target

C8166 (CHEMBL614533)
Type CELL-LINE
Organism Homo sapiens

Publication

Structure-activity relationships of anti-HIV-1 N-alkoxy- and N-allyloxy-benzimidazoles
Evans TM, Gardiner JM, Mahmood N, Smis M
Bioorg Med Chem Lett (1997) 7 : 409 -412
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 13 6.22 6.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL25496 1 6.22
CHEMBL132799 1 6.22
CHEMBL129945 1 6.22
CHEMBL133218 1 6.22
CHEMBL134085 1 6.22
CHEMBL23036 1 6.22
CHEMBL132360 1 6.22
CHEMBL133128 1 6.22
CHEMBL129988 1 6.22
CHEMBL25543 1 6.22
CHEMBL22780 1 6.22
CHEMBL277492 1 6.22
CHEMBL129944 1 6.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL25496 EC50 = 600.0 nM 6.22
CHEMBL132799 EC50 = 600.0 nM 6.22
CHEMBL129945 EC50 = 600.0 nM 6.22
CHEMBL133218 EC50 = 600.0 nM 6.22
CHEMBL134085 EC50 = 600.0 nM 6.22
CHEMBL23036 EC50 = 600.0 nM 6.22
CHEMBL132360 EC50 = 600.0 nM 6.22
CHEMBL133128 EC50 = 600.0 nM 6.22
CHEMBL129988 EC50 = 600.0 nM 6.22
CHEMBL25543 EC50 = 600.0 nM 6.22
CHEMBL22780 EC50 = 600.0 nM 6.22
CHEMBL277492 EC50 = 600.0 nM 6.22
CHEMBL129944 EC50 = 600.0 nM 6.22