Assay Detail
Functional
CHEMBL650525
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Inhibitory concentration against cell culture of Human T-cell line c8166 infected with HIV-1 IIIB strain was determined
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. 4. 2-Substituted dipyridodiazepinones as potent inhibitors of both wild-type and cysteine-181 HIV-1 reverse transcriptase enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.92 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81319 | — | — | 1 | 7.40 |
| CHEMBL145237 | — | — | 1 | 7.40 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.40 |
| CHEMBL142853 | — | — | 1 | 6.92 |
| CHEMBL288336 | — | — | 1 | 6.80 |
| CHEMBL142659 | — | — | 1 | 6.62 |
| CHEMBL144035 | — | — | 1 | 6.52 |
| CHEMBL144145 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81319 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL145237 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL142853 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL288336 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL142659 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL144035 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL144145 | — | IC50 | = | 550.0 | nM | 6.26 |