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Assay Detail

CHEMBL650533

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anti-HIV activity to protect MT-4 cells from HIV-1 induced cytopathogenicity by MTT method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type C8166
Confidence 1 — Organism
Curated By Intermediate

Target

C8166 (CHEMBL614533)
Type CELL-LINE
Organism Homo sapiens

Publication

Novel indolyl aryl sulfones active against HIV-1 carrying NNRTI resistance mutations: synthesis and SAR studies.
Silvestri R, De Martino G, La Regina G, Artico M, Massa S, Vargiu L, Mura M, Loi AG, Marceddu T, La Colla P.
J Med Chem (2003) 46 : 2482 -2493
PubMed 12773052 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 8.40 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL315349 1 8.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL315349 EC50 = 4.0 nM 8.40