Assay Detail
Binding
CHEMBL650541
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]PK11195 binding from peripheral benzodiazepine receptor in MA-10 mouse tumor Leydig cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Leydig |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.00 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63154 | — | — | 1 | 8.00 |
| CHEMBL286346 | RO-54864 | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63154 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL286346 | RO-54864 | IC50 | = | 10.0 | nM | 8.00 |