Assay Detail
Functional
CHEMBL650695
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Compound was evaluated for the inhibition of p24 viral antigen production in C-8166 cells.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, enzymatic phosphorylation and antiviral activity of acyclic dienyl phosphonate derivatives of guanine
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.09 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.40 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 6.05 |
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | 5.82 |
| CHEMBL54579 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1460 | DIDANOSINE | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL484 | ADEFOVIR | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL54579 | — | EC50 | = | 8000.0 | nM | 5.10 |